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用迭代算法在计算机上对动物或临床试验的血药浓度数据{ci,ti}_1~m按药动学线性房室模型sum from 1 to n Aie~(dit)进行参数{Ai,ai}_1~n的拟合计算,为药动学参数的科学计算提供了精确和有效的方法。无论采用那一种迭代算法,模型室数n的合理确定,{Ai,ai}_1~n的迭代初始值{Ai~((o)),ai~((o))}_1~n的尽可能对精确解的近似,是迭代计算收敛和加速的重要条件。 本文在前文[1]基础上,进一步提出实现用计算机自动判别室数n及选段计算{Ai~((o)),ai((o))}_1~n的具体算法。为了便于说明,本文的理论分析和算法描述以
An iterative algorithm was used to perform the parameter {Ai, ai} _1 on the computer according to the pharmacokinetic linear compartment model sum from 1 to n Aie ~ (dit) for the plasma concentration data of animals or clinical trials {ci, ti} ~ n fitting calculation, for the scientific calculation of pharmacokinetic parameters provide an accurate and effective method. No matter which kind of iterative algorithm is used, the number of model rooms n is determined reasonably. The iterative initial values {Ai ~ ((o)), ai ~ ((o))} _1 ~ n of {Ai, ai} Probably an approximation to the exact solution is an important condition for iteratively calculating convergence and acceleration. On the basis of the previous article [1], this paper further proposes a computer-based algorithm to automatically determine the number of rooms n and the segment selection {Ai ~ ((o)), ai ((o))} _1 ~ n. In order to facilitate the description, the theoretical analysis and algorithm described in this article