近年来, 口腔癌的发病率在许多国家有上升趋势。白斑属于口腔黏膜癌前病变,其癌变率为 7% ~15%,非均质性白斑的癌变率高达 14% ~50% [1]。因此,准确判断口腔癌前病损的预后及阻断口腔癌前病变的发展是预防口腔癌的重要措施。目前,中外学者多提倡将癌变过程中的生物学标志物 In recent years, the incidence of oral cancer has been on the rise in many countries. Leukoplakia is a precancerous lesion of the oral mucosa with a canceration rate of 7% to 15% and a heterogeneous white spot rate of up to 14% to 50% [1]. Therefore, to accurately determine the prognosis of oral precancerous lesions and block the development of oral precancerous lesions is an important measure to prevent oral cancer. At present, Chinese and foreign scholars advocate more biomarkers in carcinogenesis