核基质是细胞核内一个精密的动态变化的蛋白网络结构 ,它不仅构成细胞核的支架结构 ,而且参与诸如DNA复制、基因表达调控、RNA加工装运等重要生命过程。核基质作为反式作用因子与MARs相互作用在各种层次上对基因表达进行调控 ,并通过许多途径参与细胞癌变过程。本文从核基质结构、DNA复制、基因调控、核基质与肿瘤和细胞凋亡的关系等方面进行综述 The nuclear matrix is ​​a sophisticated dynamic network of protein networks in the nucleus that not only forms the scaffold structure of the nucleus, but also participates in important life processes such as DNA replication, gene expression regulation, RNA processing and shipping. The nuclear matrix as a trans-acting factor interacts with MARs to regulate gene expression at various levels and is involved in the carcinogenesis of cells through many pathways. This review summarizes the relationship between nuclear matrix structure, DNA replication, gene regulation, nuclear matrix and tumor and apoptosis