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目的探讨冠心病患者血清骨保护素(OPG)和高敏C反应蛋白(hsCRP)水平变化及其临床意义。方法冠心病患者45例分为急性心肌梗死(AMI组,15例)、不稳定型心绞痛(UAP组,15例)和稳定型心绞痛(SAP组,15例);其中,主要冠状动脉狭窄≥50%为单支者23例、双支者12例、三支者10例。检测治疗前和治疗后1、2和4周血清OPG及hsCRP。健康人15例作为对照组。结果治疗前,冠心病患者的血清OPG和hsCRP水平均高于对照组(P<0.01)。治疗后1、2和4周,冠心病患者的血清OPG和hsCRP水平均降低(P<0.01),但仍然高于对照组(P<0.05或P<0.01)。冠心病患者血清OPG和hsCRP水平随着病情严重程度加重而升高(P<0.05)。结论血清OPG和hsCRP可作为评估冠心病患者病情严重程度的预测因素。
Objective To investigate the changes of serum osteoprotegerin (OPG) and high sensitivity C-reactive protein (hsCRP) in patients with coronary heart disease and its clinical significance. Methods 45 patients with coronary heart disease were divided into acute myocardial infarction (AMI group, 15 cases), unstable angina pectoris (UAP group, 15 cases) and stable angina pectoris (SAP group, 15 cases). Among them, the main coronary stenosis≥50 % For the single branch in 23 cases, double branch in 12 cases, three in 10 cases. Serum OPG and hsCRP were measured before treatment and 1, 2 and 4 weeks after treatment. Fifteen healthy people served as the control group. Results Before treatment, serum OPG and hsCRP levels in patients with coronary heart disease were higher than those in the control group (P <0.01). Serum levels of OPG and hsCRP were lower in patients with coronary heart disease at 1, 2 and 4 weeks after treatment (P <0.01), but still higher than those in the control group (P <0.05 or P <0.01). Serum levels of OPG and hsCRP in patients with coronary heart disease increased with the severity of the disease (P <0.05). Conclusions Serum OPG and hsCRP can be used as predictors of the severity of coronary heart disease.