目的　观察榴弹对颅脑的致伤特点和规律 ,为战伤救治提供依据。方法　电引爆离地面 7m高的榴弹 ,将 3 6只绵羊布放于距爆心 6～ 48m处 ,致伤时测量冲击波超压和破片速度 ,致伤后进行病理学观察。结果　颅脑破片伤的发生率为破片伤动物的 3 2 % ,伤后速发死亡率为 75 % ,伤后 6h时达 10 0 %。颅脑贯通伤和盲管伤的发生率分别为 75 %和 2 5 % ,伤道污染严重。 5 0 %的动物头颅缺失 ,颅底粉碎性骨折的动物占 5 0 %。脑表面出血广泛 ,最远可波及延髓 ,镜下在距伤道 4cm处也可见出血、水肿、小血管破裂和神经元变性。颅脑爆炸伤可合并各部位的破片伤 ,其中以腹部和四肢最多 ,均为 62 .5 % ,其次是胸部合并伤 ,为 5 0 %。全部颅脑爆炸伤动物均合并有中度以下的肺脏冲击伤。结论　爆炸榴弹对颅脑的毁损性大 ,损伤范围广 ,颅骨缺损多 ,颅底易骨折 ,伤道污染重 ,合并伤多 Objective To observe the traits and rules of grenades on brain injury and provide basis for the treatment of war injuries. Methods Detachment of 7m high grenades from the ground and placement of 36 sheeps at 6 ~ 48m away from the heart of the detonator were performed. Pathological over-pressure and fragment velocity were measured during injury and pathological changes were observed after injury. Results The incidence rate of craniocerebral rupture was 32% of the rupture animals, and the mortality rate was 75% after injury and 100% at 6h after injury. The incidence of craniocerebral penetrant injury and blind duct injury were 75% and 25%, respectively, with severe wound pollution. Fifty percent of animals had skull defects and 50% of skull base comminuted fractures. Extensive brain surface hemorrhage, can spread to the medulla oblongata, microscopic 4cm away from the injury can also be seen bleeding, edema, small vessel rupture and neuronal degeneration. Brain blast injury can be combined with various parts of the wounded, with the most abdomen and limbs, were 62.5%, followed by chest injury, 50%. All brain blast injuries were combined with moderate lung injury. Conclusion Explosive grenade damage to the brain is large, a wide range of injury, skull defects, skull base easy to fracture, heavy pollution, injuries and more