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目的:探讨滤除白细胞输血技术在临床输血中的应用效果。方法:选取永康市第一人民医院2017年1月至2018年12月收治的需大量输血的大出血患者120例，根据就诊单双号分为两组各60例。对照组按规范直接输血，观察组滤除白细胞后再输血，比较两组凝血功能指标、血液流变学指标、细胞免疫功能指标、免疫球蛋白指标、体温、非溶血性发热性输血反应发生率。结果:输血后，观察组凝血酶原时间、活化部分凝血活酶时间、凝血酶时间分别为（12.39±1.41）s、（26.84±6.47）s、（14.32±3.14）s，均短于对照组的（15.54±2.03）s、（34.23±7.59）s、（20.98±4.27）s（n t=9.872、5.740、9.733，均n P < 0.05）；观察组红细胞比容、红细胞沉降率、血浆黏度分别为（39.28±2.17）%、（25.97±4.10）mm/h、（2.19±0.45）mp·s，对照组分别为（34.64±4.52）%、（21.85±3.64）mm/h、（1.76±0.42）mp·s，两组差异均有统计学意义（ n t=9.87、5.74、9.73，均n P < 0.05）；对照组输血前后CD n 3+、CDn 4/CDn 8、免疫球蛋白G、免疫球蛋白A、免疫球蛋白M差异均有统计学意义（n t=5.99、5.91、5.77、5.80、5.85，均n P 0.05）；观察组体温为（36.58±0.50）℃，低于对照组的（37.16±0.57）℃（ n t=5.95，n P < 0.05）；观察组非溶血性发热性输血反应发生率为1.67%，低于对照组的13.33%（χ n 2=5.88，n P < 0.05）。n 结论:滤除白细胞用于输血中，可有效恢复患者的体温，改善其凝血功能和血液流变学指标，减轻输血对患者免疫功能、体温的影响，减少非溶血性发热性输血反应。“,”Objective:To investigate the clinical application effects of leukocyte-filtered blood transfusions.Methods:A total of 120 patients with massive bleeding who received transfusions of a large amount of blood in the First People\'s Hospital of Yongkang, China from January 2017 to December 2018 were included in this study. They were divided into a control group (even numbers) and an observation group (odd numbers) according to registration numbers. The control group was subjected to direct blood transfusion. The observation group was given leukocyte-filtered blood transfusions. Coagulation function index, hemorheological index, cellular immune function, immunoglobulin level, body temperature, and the incidence of febrile non-hemolytic transfusion reactions were compared between the two groups.Results:After blood transfusions, prothrombin time, activated partial thromboplastin time, thrombin time in the observation group were (12.39 ± 1.41) seconds, (26.84 ± 6.47) seconds, and (14.32 ± 3.14) seconds, which were significantly shorter than those in the control group [(15.54 ± 2.03) seconds, (34.23 ± 7.59) seconds, (20.98 ± 4.27) seconds, n t = 9.872, 5.740, 9.733, all n P < 0.05]. Hematocrit, erythrocyte sedimentation rate, and plasma viscosity in the observation group were (39.28 ± 2.17)%, (25.97 ± 4.10) mm/h, and (2.19 ± 0.45) mp·s respectively, and those in the control group were (34.64 ± 4.52)%, (21.85 ± 3.64) mm/h, and (1.76 ± 0.42) mp·s respectively. There were significant differences in these indices between the two groups ( n t = 9.87, 5.74, 9.73, all n P < 0.05). There were significant differences in CD n 3+, CDn 4/CDn 8, immunoglobulin G, immunoglobulin A, and immunoglobulin M between before and after blood transfusions in the control group (n t = 5.99, 5.91, 5.77, 5.80, 5.85, all n P 0.05). After blood transfusions, body temperature was significantly lower in the observation group than in the control group [(36.58 ± 0.50) ℃ n vs. (37.16±0.57)℃, n t = 5.95, n P < 0.05]. The incidence of febrile non-hemolytic transfusion reactions was significantly lower in the observation group than in the control group (1.67% n vs. 13.33%, n χ2 = 5.88, n P < 0.05).n Conclusion:Leukocyte-filtered blood transfusions can effectively restore the patient\'s body temperature to normal, improve coagulation function index and hemorheological index, reduce the impact of blood transfusions on the patient\'s immune function, and reduce febrile non-hemolytic transfusion reactions.