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最近有几项随机临床试验已证明,α-干扰素治疗慢性活动性乙型肝炎(CAH)有效。作者报道用α-干扰素治疗CAH的远期疗效,评价了预测治疗应答的因素以及使用不同剂量和类型干扰素的效果。 1984年1月～1992年10月,作者用α-干扰素共治疗62例CAH患者(男43例,女19例;年龄10～67岁,平均36岁)。所有患者的ALT长期升高,血清HBsAg持续阳性至少6个月;治疗前有59例(95％)
Several recent randomized clinical trials have demonstrated that alpha-interferon is effective in treating chronic active hepatitis B (CAH). The authors report the long-term efficacy of a-interferon in the treatment of CAH, evaluating the factors that predict therapeutic response and the effects of using different doses and types of interferon. From January 1984 to October 1992, the authors treated 62 CAH patients (43 males and 19 females; aged 10-67 years, mean 36 years) with α-interferon. All patients had long-term ALT, serum HBsAg persistently positive for at least 6 months; before treatment, 59 (95%)