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目的:观察抗早颗粒治疗特发性中枢性性早熟(ICPP)女童的临床疗效。方法:将特发性中枢性性早熟(痰火互结证)女童80例随机分为两组各40例,治疗组予抗早颗粒剂治疗,对照组予曲普瑞林治疗。两组疗程均为6个月,观察比较两组中医证候、体质指数(BMI)、血清黄体生成素(LH)、促卵泡激素(FSH)、雌二醇(E2)及骨龄等变化。结果:治疗组与对照组总有效率分别为70.0%和73.3%,治疗组优于对照组(P>0.05);治疗组可以改善性早熟女童中医证候;两组治疗后患儿子宫卵巢容积、乳核直径、LH、FSH、E2、骨龄和年龄的比值(△BA/△CA)较治疗前均减少(P<0.05);治疗组患儿体质指数较治疗前降低(P<0.05)。结论:抗早颗粒剂治疗痰热互结型ICPP女童疗效确切,能改善患儿临床症状,延缓骨龄,同时控制患儿体重,降低体质指数。
Objective: To observe the clinical efficacy of Kang Zao Granule in the treatment of idiopathic central precocious puberty (ICPP) girls. Methods: Eighty girls with idiopathic central precocious puberty (phlegm-fire cross-over card) were randomly divided into two groups of 40 cases. The treatment group was treated with Kangsao Granule and the control group was treated with triptorelin. The two groups were treated for 6 months. The changes of TCM syndrome, body mass index (BMI), serum LH, FSH, E2 and bone age were observed and compared between the two groups. Results: The total effective rate was 70.0% in the treatment group and 73.3% in the control group, and the treatment group was superior to the control group (P> 0.05). The treatment group could improve the TCM syndrome of the precocious girls; the uterine ovary volume (P <0.05). The body mass index of the treated group was lower than that before treatment (P <0.05). The ratio of milk core diameter, LH, FSH, E2, bone age and age (△ BA / △ CA) Conclusion: Anti-Zao Granule treatment of phlegm-heat ICPP girls with definite effect can improve the clinical symptoms of children, delay bone age, while controlling the weight of children and lower body mass index.