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目的比较5种宫颈癌筛查方法在南疆维族宫颈癌高发地区的应用价值,评价理想的筛查方案。方法 2 116例年龄25~65岁、有性生活的女性均行肉眼下醋酸及碘试验联合传统宫颈巴氏涂片检查,并结合阴道镜下碘试验及HPV-DNA检测;以组织病理学结果为诊断金标准,比较不同筛查方法的诊断效果。结果巴氏涂片对宫颈上皮内高度病变敏感度、特异度、阳性预测值、阴性预测值分别为82.35%,85.69%,8.59%和99.66%;肉眼下醋酸试验分别为50.00%,81.36%,4.35%和99.01%;肉眼下碘试验分别为38.24%,90.44%,6.57%和98.91%;阴道镜下碘试验分别为90.00%,57.43%,9.47%,99.15%;HPV-DNA检测法分别为41.18%,95.47%,48.28%,86.58%。结论传统宫颈刮片细胞学涂片法与肉眼观察联合并于阴道镜下取材活检,可作为南疆维族聚集区宫颈癌早期筛查方法。
Objective To compare the application value of five kinds of cervical cancer screening methods in the high incidence area of Uighur cervical cancer in southern Xinjiang and evaluate the ideal screening program. Method 2 A total of 116 women aged 25-65 years with sex life underwent visual acuity with acetate and iodine test combined with traditional papillary Pap smear and colposcopy iodine test and HPV-DNA test. Histopathological findings To diagnose the gold standard, the diagnostic efficacy of different screening methods is compared. Results The sensitivity, specificity, positive predictive value and negative predictive value of Pap smear for cervical intraepithelial lesion were 82.35%, 85.69%, 8.59% and 99.66%, respectively. Acetic acid test was 50.00% and 81.36% 4.35% and 99.01% respectively. The iodine test under naked eye was 38.24%, 90.44%, 6.57% and 98.91% respectively. The colposcopic iodine test was 90.00%, 57.43%, 9.47% and 99.15% 41.18%, 95.47%, 48.28%, 86.58%. Conclusion Traditional cervical smear cytology smears combined with the naked eye observation and colposcopy biopsy can be used as early detection of cervical cancer in Uygur ethnic agglomeration in southern Xinjiang.