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目的 :探讨甘露醇注射液散在性输液反应发生的原因和对策。方法 :结合生产实践和文献资料 ,针对制剂生产的主要环节—活性炭、pH值、灭菌条件等相关因素进行分析。结果 :细菌内毒素的含量偏高是其主要原因。结论 :严格控制上述生产条件是降低其内毒素含量的有效对策。
Objective: To investigate the causes and countermeasures of mannitol injection in sporadic infusion reaction. Methods: According to the production practice and the literature, the related factors such as activated carbon, pH value, sterilization conditions and so on were analyzed. Results: The high content of bacterial endotoxin is the main reason. Conclusion: Strict control of the above production conditions is an effective countermeasure to reduce their endotoxin content.