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目的研究大鼠肝卵圆细胞的可塑性。方法用大鼠肝卵圆细胞系LE/6细胞种植于25只裸鼠皮下,观察有无新生物生长,新生物石蜡切片后通过苏木素-伊红(HE)染色初步鉴定其性质。结果15只(60%)裸鼠皮下种植肝卵圆细胞后,肝卵圆细胞转分化为间叶组织瘤。结论肝卵圆细胞具有向间叶组织分化的能力。
Objective To study the plasticity of rat hepatic oval cells. Methods Rat hepatic oval cell line LE / 6 cells were implanted subcutaneously in 25 nude mice to observe the presence or absence of new growth. The new paraffin sections were initially identified by hematoxylin and eosin (HE) staining. Results 15 (60%) nude mice subcutaneously planted hepatic oval cells, hepatic oval cells transdifferentiated to mesenchymal tumor. Conclusion Hepatic oval cells have the ability to differentiate into mesenchyme.