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我们在1981年初步观察流行性出血热(EHF)各期血管紧张素Ⅱ(ATⅡ)水平的基础上,于1984年又对肾素—血管紧张素—醛固酮系统(RAAS)各组成分—血管紧张素Ⅰ(ATⅠ)、ATⅡ、醛固酮(ALD)的血浆含量进行了系统观察。54例患者ATⅡ从发热期开始升高,低血压及少尿期达高峰,多尿期后逐渐下降;ATⅠ各期均减低,低血压及少尿期最明显;ALD在低血压及少尿期与ATⅡ相应地增高。以上改变与病情轻重及尿素氮相平行。实验结果进一步证实RAAS与EHF休克及急性肾功能衰竭的发病有重要联系,故早期稳定体液平衡并拮抗RAAS激活及其影响。是EHF治疗的重要关键。
Based on the preliminary observation of the levels of angiotensin Ⅱ (AT Ⅱ) in various stages of epidemic hemorrhagic fever (EHF) in 1981, we retrospectively analyzed the components of the renin-angiotensin-aldosterone system (RAAS) The plasma levels of ATⅠ, ATⅡ and aldosterone (ALD) were systematically observed. 54 cases of AT II increased from the onset of fever, hypotension and oliguria reached its peak, decreased gradually after polyuria; AT Ⅰ decreased in all stages, hypotension and oliguria was the most obvious; ALD in hypotension and oliguria And AT Ⅱ increased accordingly. The above changes in severity and urea nitrogen parallel. Experimental results further confirmed that RAAS and EHF shock and acute renal failure have an important link, so early stable body fluid balance and antagonize RAAS activation and its impact. EHF treatment is an important key.