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目的探讨托吡酯、丙戊酸钠、卡马西平对脑炎后癫癇的治疗作用。方法 90例脑炎后癫癇患者依据随机化原则分为3组,分别给予上述3种药物口服治疗;比较3种药物临床治疗作用、不良反应发生率。结果丙戊酸钠组治疗总有效率最高,卡马西平组治疗总有效率最低,但3组间比较差异无统计学意义,P>0.05;3组不良反应发生率依次为10.0%,23.3%,43.3%,差异有统计学意义(P<0.05);3组发生不良反应的总数进行统计学检验,不良反应发生率差异具有统计学意义(χ2=8.877,P=0.012<0.05),托吡酯组和卡马西平组比较差异具有统计学意义(P<0.05),其他各组两两比较差异不具有统计学意义(P>0.05)。结论托吡酯与丙戊酸钠治疗癫癇的临床疗效相当,卡马西平临床应用不良反应发生率较高。
Objective To investigate the therapeutic effect of topiramate, valproate and carbamazepine on epilepsy after encephalitis. Methods 90 cases of post-encephalitis patients with epilepsy were randomly divided into three groups according to the principle of randomization. The three kinds of drugs were given orally respectively. The clinical effects and adverse reactions of the three drugs were compared. Results The total effective rate of sodium valproate group was the highest, while the total effective rate of carbamazepine group was the lowest, but there was no significant difference among the three groups (P> 0.05). The incidence of adverse reactions in the three groups were 10.0% and 23.3% , 43.3% respectively, the difference was statistically significant (P <0.05). The total number of adverse reactions in the three groups was statistically tested, the incidence of adverse reactions was statistically significant (χ2 = 8.877, P = 0.012 <0.05) Compared with carbamazepine group, the difference was statistically significant (P <0.05). There was no significant difference between the other groups (P> 0.05). Conclusion Topiramate and sodium valproate are effective in the treatment of epilepsy. Carbamazepine has a higher incidence of clinical adverse reactions.