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目的探讨脑梗死患者血浆同型半胱氨酸(Hcy)和纤维蛋白原(Fg)水平与颈动脉粥样硬化斑块稳定性的关系。方法根据颈动脉彩色超声多普勒检查结果将70例脑梗死患者分为无斑块组(14例)、不稳定斑块组(34例)和稳定斑块组(22例),测定Hcy和Fg水平。结果不稳定斑块组Hcy和Fg为(21.76±9.82)μmol/L、(3.78±0.58)g/L,均显著高于无斑块组的(14.09±3.05)μmol/L、(3.12±0.36)g/L和稳定斑块组的(16.79±3.56)μmol/L、(3.52±0.42)g/L(P<0.05,P<0.01)。随着Hcy和Fg水平的升高,颈动脉不稳定斑块的发生率升高。结论颈动脉斑块的发生及其稳定性与Hcy和Fg水平关系密切。
Objective To investigate the relationship between plasma homocysteine (Hcy) and fibrinogen (Fg) levels and the stability of carotid atherosclerosis plaque in patients with cerebral infarction. Methods Seventy patients with cerebral infarction were divided into no plaque group (14 cases), unstable plaque group (34 cases) and stable plaque group (22 cases) according to the results of color Doppler ultrasound examination of carotid artery. Hcy and Fg level. Results Hcy and Fg were (21.76 ± 9.82) μmol / L and (3.78 ± 0.58) g / L in the unstable plaque group, which were significantly higher than those in the non-plaque group (14.09 ± 3.05 μmol / L, 3.12 ± 0.36 (16.79 ± 3.56) μmol / L, and (3.52 ± 0.42) g / L respectively in the stable plaque group (P <0.05, P <0.01). As Hcy and Fg levels rise, the incidence of unstable carotid plaques increases. Conclusion Carotid plaque occurrence and stability are closely related to Hcy and Fg levels.