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目的:探讨慢性阻塞性肺疾病(COPD)患者白细胞介素6(IL-6)、白细胞介素8(IL-8)及超敏C反应蛋白(hs-CRP)水平与吸烟的关系。方法:病例组选择老年男性COPD稳定期患者80例,均为吸烟者,检测IL-6、IL-8、hs-CRP水平,据吸烟指数不同及戒烟时间长短分组比较;健康组为门诊健康查体者30例,均为男性,吸烟者与非吸烟者各15例,检测IL-6、IL-8、hs-CRP水平交比较。结果:IL-6、IL-8、hs-CRP水平及吸烟明显相关:健康组吸烟者与不吸烟者相比,IL-6、IL-8、hs-CRP水平明显增高(P<0.05);病例组IL-6、IL-8、hs-CRP水平进一步增高,且与吸烟指数呈正相关,与戒烟时间呈负相关,均有统计学意义(P<0.05)。结论:吸烟与hs-CRP、IL-6、IL-8水平有显著关系(P<0.05);吸烟在促进COPD患者hs-CRP的产生、加快气道炎症的进展中起着重要的作用。
Objective: To investigate the relationship between smoking and IL-6, IL-8 and hs-CRP levels in patients with chronic obstructive pulmonary disease (COPD). Methods: 80 elderly patients with stable COPD were enrolled in this study. All smokers were enrolled in this study. The levels of IL-6, IL-8 and hs-CRP were determined. The smoking index and smoking cessation time were compared among groups. Body in 30 cases, both men, smokers and non-smokers in 15 cases, detection of IL-6, IL-8, hs-CRP levels compared to pay. Results: The levels of IL-6, IL-8 and hs-CRP were significantly correlated with smoking. The levels of IL-6, IL-8 and hs-CRP in healthy group were significantly higher than those in non-smoker group (P <0.05) The levels of IL-6, IL-8 and hs-CRP in patients were further increased, which were positively correlated with smoking index and negatively correlated with smoking cessation time (all P <0.05). Conclusion: Smoking has a significant relationship with the levels of hs-CRP, IL-6 and IL-8 (P <0.05). Smoking plays an important role in promoting the production of hs-CRP and accelerating the progression of airway inflammation in COPD patients.