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四川省第二届肝癌学术会议于1990年12月20～22日在宜宾市召开,到会代表90余人,共收到论文56篇,其中大会交流33篇。报道如下。一、基础、发病机制华西医科大学肿瘤研究所制备一株新的抗人肝癌单克隆抗体HL_2,经ELISA与ABC试验均表明其特异性好、阳性率较高。对病理学诊断、放射免疫显象定位诊断及导向洽疗等均有一定意义。第三军医大学(下称三军医大)西南医院对微量元素致肝癌的发病机制进行了研究,从实验性肝癌大鼠模型与临床病人证明硒对肝癌的发生有抑制作用并与自由基有关。测定48例肝癌与54例肝硬化血清过氧化脂质(LPO)代谢产物丙二醇及谷胱甘肽过氧化酶(GSH-PX),发现肝病变初期及癌前期LPO增加,而肝癌形成期则降低,GSH-PX亦明
The second Sichuan Hepatic Cancer Conference was held in Yibin City from December 20 to 22, 1990. More than 90 delegates attended the conference and received 56 papers, of which 33 were exchanged. The report is as follows. I. Basis and pathogenesis A new anti-human hepatoma monoclonal antibody HL_2 was prepared by the Cancer Research Institute of West China University of Medical Sciences. Both ELISA and ABC tests showed that the specificity was good and the positive rate was high. Diagnosis of pathology, radioimmunoimaging, localized diagnosis, and guidance-based therapy are of some significance. The Third Military Medical University (hereinafter referred to as the Three Military Medical University) Southwest Hospital studied the pathogenesis of liver cancer caused by microelements. It was proved from the experimental liver cancer rat model and clinical patients that selenium had inhibitory effect on the occurrence of liver cancer and was related to free radicals. The levels of LPO, a metabolite of serum lipid peroxidation (LPO) in 48 cases of hepatocellular carcinoma and 54 cases of liver cirrhosis, were measured. It was found that LPO increased in the early stage and precancerous stage of liver disease, while the stage of hepatocarcinogenesis decreased. , GSH-PX also clear