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目的探讨帕罗西汀治疗脑卒中抑郁(PSD)患者的临床疗效。方法选取2012年1月至2014年12月长春市中心医院收治的PSD患者206例为研究对象,按随机数字表法分为观察组和对照组,每组103例。观察组患者给予帕罗西汀治疗,对照组患者给予阿米替林治疗,比较两组患者临床疗效和不良反应。结果观察组患者治疗总有效率为91.3%,对照组治疗总有效率为76.7%,观察组总有效率明显高于对照组,差异有统计学意义(P<0.05);两组患者治疗前汉密尔顿抑郁量表评分差异无统计学意义(P>0.05);治疗后8、12周观察组汉密尔顿抑郁量表评分明显低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为11.7%,对照组不良反应发生率为24.3%,差异有统计学意义(P<0.05)。结论帕罗西汀治疗PSD效果显著,不良反应少,安全性高。
Objective To investigate the clinical efficacy of paroxetine in the treatment of stroke depression (PSD). Methods A total of 206 PSD patients admitted from January 2012 to December 2014 in Changchun Central Hospital were enrolled and divided into observation group (n = 103) and control group (n = 103) according to random number table. Patients in the observation group were treated with paroxetine, patients in the control group were treated with amitriptyline, and clinical efficacy and adverse reactions were compared between the two groups. Results The total effective rate was 91.3% in the observation group and 76.7% in the control group. The total effective rate in the observation group was significantly higher than that in the control group (P <0.05). Before treatment, Hamilton (P> 0.05). The scores of Hamilton Depression Scale in the observation group at 8 and 12 weeks after treatment were significantly lower than those in the control group (P <0.05). Adverse reactions of the observation group occurred The rate of adverse reactions was 11.7% in the control group and 24.3% in the control group, the difference was statistically significant (P <0.05). Conclusion Paroxetine treatment of PSD significant effect, less adverse reactions, high safety.