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目的 观察比较正常妊娠和妊高征妇女血浆D -二聚体 (DD)含量变化。方法 采用ELISA双抗体夹心法 ,检测正常妊娠和妊高征孕妇各 3 0例及非妊娠妇女 2 0例的血浆DD含量变化。结果 正常妊娠和妊高征两组血浆DD含量均高于非孕妇女 (均P <0 0 1) ,妊高征组高于正常妊娠组 (P <0 0 1) ;在妊高征组中轻、中、重度患者血浆DD含量随病情加重逐渐升高并有显著性意义 (P <0 0 1)。结论 正常妊娠孕妇血浆DD水平升高 ,妊高征患者尤为明显 ,动态检测孕妇血浆中DD含量变化 ,对妊高征的早期诊断与防治有重要意义。
Objective To observe the changes of plasma D - dimer (DD) levels in women with normal pregnancy and pregnancy induced hypertension. Methods ELISA double antibody sandwich method was used to detect changes of plasma DD in 30 cases of normal pregnant and PIH pregnant women and 20 cases of non-pregnant women. Results The levels of plasma DD in both normal and PIH groups were significantly higher than those in non-pregnant women (all P <0.01), those in PIH group were higher than those in normal pregnancy group (P <0.01) The levels of plasma DD in mild, moderate and severe patients increased gradually with the severity of the disease and were significant (P <0.01). Conclusion The level of plasma DD in normal pregnant women is elevated and the PIH is more obvious. The dynamic changes of DD in plasma of pregnant women are of great significance in the early diagnosis and prevention of PIH.