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作者在1957—1969年总结3055例造血系统恶性肿瘤,发现2例发展成继发性非造血系统实体瘤(0.06％),其中1例为非何杰金淋巴瘤(NHL),经1500rad放疗,3年后发展为肺鳞状细胞癌。另1例为慢性淋巴细胞白血病(CLL),以瘤可宁(CLB)治疗,于6个月后出现前列腺癌。作者又于1970—1985年总结2262例造血系统恶性肿瘤,其中26例(1.14％)经化疗和/或放疗后继发非造血系统肿瘤。其原发病为:CLL及NHL各7例、多发性骨髓瘤(MM)6例、何杰金病(HD)4例、急性髓细胞白血病(AML)及急性早幼粒细胞白血病(APL)各1例。所用药物有CLB、环磷酰胺、柔红霉素、长春新硷、阿糖胞苷、马法兰及COPP、MOPP方案。继发的肿瘤包括:肺癌7、结肠癌6、胃癌4、膀胱癌及食管癌各3、直肠癌2、胰腺癌1例,不包括皮肤癌在内。发生继发性肿瘤的平均时间(月)为:CLL50(9—144)、NHL62(36—105)、MM54(39—91)、HD52(43—69)、AML38、APL5。诊断继发性肿瘤后的存活期平均仅为7.3月(1—23)。作者所见26例继发性非造血系统肿瘤的共同点是
The authors summarized 3055 hematopoietic malignancies from 1957 to 1969 and found that 2 developed into secondary non-hematopoietic solid tumors (0.06%), one of whom was non-Hodgkin’s lymphoma (NHL) 3 years after the development of lung squamous cell carcinoma. The other 1 patient was chronic lymphocytic leukemia (CLL) treated with clonidine (CLB) and developed prostate cancer after 6 months. The authors summarized 2262 hematopoietic malignancies in 1970-1985, of which 26 (1.14%) had non-hematopoietic tumors secondary to chemotherapy and / or radiotherapy. The primary disease was: 7 cases of CLL and NHL, 6 cases of multiple myeloma (MM), 4 cases of Hodgkin’s disease (HD), acute myeloid leukemia (AML) and acute promyelocytic leukemia (APL) One case each. The drugs used are CLB, cyclophosphamide, daunorubicin, vincristine, cytarabine, melphalan and COPP, MOPP program. Secondary tumors include: lung cancer 7, colon cancer 6, gastric cancer 4, bladder cancer and esophageal cancer 3, rectal cancer 2, pancreatic cancer in 1 case, excluding skin cancer. The mean time (months) for developing secondary tumors was CLL50 (9-144), NHL62 (36-105), MM54 (39-91), HD52 (43-69), AML38, APL5. Survival after diagnosis of secondary tumors was only an average of 7.3 months (1-23). The authors found 26 cases of secondary non-hematopoietic tumors have in common