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[目的]观察宁络护膜养胃合剂对大鼠急性胃黏膜损伤保护作用。[方法]使用随机平行对照方法,将清洁级SD大鼠(体重180～220g)编号按随机数字标法随机分为六组(12只/组),雌雄各半,分笼喂养。各组分别灌胃宁络护膜养胃合剂(高、中、低剂量)、气滞胃痛冲剂、硫糖铝混悬凝胶,再用无水乙醇诱导SD大鼠急性胃黏膜损伤。肉眼观察大鼠胃黏膜损伤进行评分;取胃部受损严重部分光学显微镜下观察胃黏膜细胞受损情况。[结果]宁络护膜养胃合剂中、高剂量组、硫糖铝混悬凝胶组损伤评分均低于空白对照组(P<0.05),宁络护膜养胃合剂高剂量组评分最低(P<0.01);宁络护膜养胃合剂中、高剂量组损伤评分均低于气滞胃痛组(P<0.05,P<0.01);宁络护膜养胃合剂组大鼠的胃黏膜与正常组大鼠相似,黏膜几乎未被破坏;硫糖铝混悬凝胶组大鼠胃黏膜破坏也较少。[结论]宁络护膜养胃合剂能显著降低无水乙醇引起的大鼠急性胃黏膜损伤,促进胃黏膜上皮细胞修复,从而起到保护胃黏膜的作用。
[Objective] To observe the protective effect of Ningluo Huayang Mixture on acute gastric mucosal injury in rats. [Method] Using randomized parallel control method, clean SD rats (weight 180 ~ 220g) were randomly divided into six groups (12 / group) according to the random number standard method. The rats in each group were given Shennongjianjianweishen (high, medium and low dose), Qiweizhitong granule and sucralfate suspension gel, respectively, and then were induced into acute gastric mucosal injury in SD rats by ethanol. Macroscopic observation of gastric mucosal injury in rats was scored; severe damage to the stomach was observed under light microscope, gastric mucosal cell damage. [Results] The scores of injury of Ningluo Nanyuanye Mixture in medium and high dosage groups and sucralfate suspension gel group were lower than those in blank control group (P <0.05), and Ningluo Nanyu Yangwei Mixture high-dosage group was the lowest (P <0.01). The scores of injury of Ningluo Nanyunjianghuai Mixture group were lower than those of Qi stagnation and stomach pain group (P <0.05, P <0.01) Similar to the normal group, the mucosa almost did not destroy, and the sucralfate suspension group had less gastric mucosal damage. [Conclusion] Ningluo Lamyangyangwei Mixture can significantly reduce the acute gastric mucosal injury induced by ethanol in rats and promote the repair of gastric mucosal epithelial cells, thereby protecting the gastric mucosa.