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近年来区域化疗对实体肿瘤治疗作用日益受到重视,但对结直肠癌术前区域动脉灌注化疗报告极少。作者对30例结直肠癌患者行术前选择性区域动脉灌注化疗,术后标本组织病理学观察发现,在肿瘤边缘出现明显坏死灶,区别于发生在肿瘤中心的自然坏死。所有病例均发现癌细胞发生核固缩、碎裂、胞浆凝固、坏死,细胞间质水肿、纤维增生、炎性细胞浸润,血管出现内膜增生、血管炎及血栓形成,均以轻到中度变化
In recent years, the role of regional chemotherapy in the treatment of solid tumors has received increasing attention. However, few reports of preoperative regional arterial infusion chemotherapy have been reported. The authors performed preoperative regional arterial infusion chemotherapy in 30 patients with colorectal cancer. Histopathological examination of the specimens revealed that necrotic lesions appeared at the edge of the tumor, which was different from natural necrosis at the center of the tumor. In all cases, nuclear condensation, fragmentation, cytoplasmic coagulation, necrosis, interstitial edema, fibroplasia, inflammatory cell infiltration, intimal hyperplasia, vasculitis, and thrombosis were observed in all cancer cells. Change in degree