利妥昔单抗治疗慢性淋巴细胞白血病合并膜性肾病一例

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报道1例慢性淋巴细胞白血病合并膜性肾病。患者临床肾损害表现为肾病范围蛋白尿,血清抗磷脂酶A2受体抗体阴性,肾组织病理诊断为不典型膜性肾病,经利妥昔单抗治疗慢性淋巴细胞白血病后外周血淋巴细胞比例下降、淋巴结缩小及蛋白尿缓解。提示膜性肾病继发于慢性淋巴细胞白血病,且利妥昔单抗单药治疗有效,避免了不必要的化疗药物应用。
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