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目的:观察α-硫辛酸治疗糖尿病周围神经病变的疗效及对胰岛素样生长因子-Ⅰ(IGF-1)的影响。方法:65例糖尿病周围神经病变患者均在原降糖治疗方案的基础上,采用α-硫辛酸剂量为600 mg/d,静脉滴注,连用2周为1个疗程;比较治疗前后临床疗效和神经传导速度、IGF-1的变化。结果:α-硫辛酸治疗前后症状评分、神经传导速度、IGF-1进行比较,差异均有统计学意义(P<0.05)。结论:α-硫辛酸可以改善糖尿病周围神经病变患者临床症状,症状改善可能与上调IGF-Ⅰ水平有关。
Objective: To observe the therapeutic effect of α-lipoic acid on diabetic peripheral neuropathy and its effect on insulin-like growth factor-Ⅰ (IGF-1). Methods: Sixty-five patients with diabetic peripheral neuropathy were treated with hypoglycaemic regimen. The dose of α-lipoic acid was 600 mg / d. The patients were given intravenous drip for 2 weeks. The curative effect and nerve Conduction velocity, changes in IGF-1. Results: There was significant difference in symptom scores, nerve conduction velocity and IGF-1 before and after treatment with α-lipoic acid (P <0.05). Conclusion: Alpha-lipoic acid can improve the clinical symptoms of patients with diabetic peripheral neuropathy. The improvement of symptoms may be related to the up-regulation of IGF-Ⅰlevel.