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利用支撑液膜控制离子在隔离的两相中流动传输,同时添加有机小分子协同液膜界面形成模板,诱导纳米晶体进行嵌段组合团聚成非致密型超结构,得到一种由纳米片状亚单元卷曲后组装形成的新型介孔球状纳米羟基磷灰石材料.TEM,XRD,BET等结果表明.产物纳米羟基磷灰石平均孔径为17.5 nm.细胞毒性实验表明,不同浓度的细胞存活率高于80%,细胞毒性为1级,可认为材料具有良好的细胞相容性.FT-IR,UV光谱结果表明产物能有效地对鬼臼毒素进行载药包裹,平均载药量为12.9%,包封率为65.5%.这种新型介孔超结构HA在酶、蛋白质的同定和分离、约物转染等方面具有其潜在的应用价值.“,”A new kind of mesoporous spherical HA nanoparticles which formed by the curling of the sheet-like subunit was obtained by supported liquid membrane(SLM)combining with small organic molecules method,in which SLM controlled the transportation of the ions between the two separated phases,and the small organic molecules cooperated with the SLM to induce the nanocrystals to combine and reunite to form noncompacted superstructure.The results of TEM.XRD and BET showed that the average pore diameter of the sample obtained was 17.5 nm.The cell toxic experiment showed that the survival ratio of different cell concentration was more than 80%and the cell toxicity of pure material was A1.which means the HA obtained has nice biocompatibility.The FT-IR and UV tests demonstrated that the material could enwrap podophyllotoxin efficiently.The average drug loading was 12.9%.and entrapment efficiency was 65.5%.In conclusion,this new kind of material has potential applications on immobilization of enzyme,protein macromolecular adsorption,catalytic reaction,drug store,and so on.