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报告1例发生于腰背部的原发性皮肤弥漫大B细胞淋巴瘤。患者女,46岁。腰背部肿块1年余。皮损组织病理学检查示:表皮厚度大致正常,真皮乳头水肿,可见一无浸润带,真皮全层灶性或弥漫性单一核细胞浸润,细胞异形,部分细胞核细胞质比例大,核仁清晰,并可见多数核分裂象。免疫组化示:CD20、CD45RO、CD79a、多发性骨髓瘤原癌基因(MUM)-1、配对盒基因(PAX)-5阳性。诊断:原发性皮肤弥漫大B细胞淋巴瘤。治疗:予以R-CHOP(利妥昔单抗、环磷酰胺、吡柔比星、长春新碱、泼尼松)方案化疗,肿块较前缩小。
One case of primary cutaneous diffuse large B-cell lymphoma occurred in the lower back. Female patient, 46 years old. Lower back lumps more than 1 year. Histopathological examination showed that the thickness of epidermis was almost normal, dermal papilla edema showed a non-invasive zone, full-thickness dermis or diffuse mononuclear cell infiltration, abnormal cell shape, a large proportion of the nuclear cytoplasm, clear nucleoli and Most mitotic figures are visible. Immunohistochemistry showed: CD20, CD45RO, CD79a, multiple myeloma proto-oncogene (MUM) -1, paired box gene (PAX) -5 positive. Diagnosis: Primary skin diffuse large B cell lymphoma. Treatment: R-CHOP (rituximab, cyclophosphamide, pirarubicin, vincristine, prednisone) regimen chemotherapy, compared with the previous shrinkage.