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目的探讨国产海藻酸钠载药微球在原发性肝癌肝动脉插管化疗栓塞术(TACE)治疗中的安全性。方法 60例原发性肝癌患者,随机分为海藻酸钠组和碘化油组,每组30例。海藻酸钠组接受国产海藻酸钠载药微球进行动脉化疗栓塞,碘化油组采用碘化油进行动脉化疗栓塞,评价血常规、肝功能以及并发症情况。结果 TACE术后,两组患者白细胞、红细胞和血小板降低情况比较差异无统计学意义(P>0.05)。两组患者总胆红素(TBIL)增高、间接胆红素(IBIL)增高、谷丙转氨酶(ALT)增高、谷草转氨酶(AST)增高和白蛋白(ALB)降低情况比较差异无统计学意义(P>0.05)。海藻酸钠组患者并发腹痛16.7%(5/30)低于碘化油组的60.0%(18/30),差异有统计学意义(P<0.05)。两组患者其他并发症比较,差异无统计学意义(P>0.05)。结论国产海藻酸钠载药微球在原发性肝癌TACE治疗中是安全的,可在临床使用。
Objective To investigate the safety of domestic sodium alginate drug-loaded microspheres in the treatment of primary hepatic artery transcatheter arterial chemoembolization (TACE). Methods Sixty patients with primary liver cancer were randomly divided into sodium alginate group and iodized oil group, 30 cases in each group. Alginate group received domestic sodium alginate drug-loaded microspheres for arterial chemoembolization, iodized oil group with iodized oil for arterial chemoembolization, evaluation of blood, liver function and complications. Results There was no significant difference in the reduction of leucocyte, erythrocyte and platelet between the two groups after TACE (P> 0.05). There was no significant difference in total bilirubin (TBIL), IBIL, ALT, AST and ALB between the two groups P> 0.05). The incidence of abdominal pain in patients with sodium alginate group was 16.7% (5/30) lower than that in iodized oil group (60.0%, 18/30), the difference was statistically significant (P <0.05). The other two groups of patients with complications, the difference was not statistically significant (P> 0.05). Conclusion The domestic sodium alginate drug-loaded microspheres in the treatment of primary liver cancer TACE is safe and can be used clinically.