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目的:探讨调脂治疗对缺血性脑血管病(ICVD)患者颈动脉斑块的影响。方法:78例有颈动脉粥样硬化斑块的ICVD患者随机分为血脂康组和对照组:血脂康组口服血脂康及阿司匹林6个月,对照组仅口服阿司匹林。观察并比较2组治疗前、后颈动脉内-中膜厚度(IMT)、血流阻力指数(RI)及血脂、血清一氧化氮(NO)、氧化低密度脂蛋白(ox-LDL)水平的变化。结果:与治疗前相比,治疗后血脂康组胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白胆固醇(LDL-C)、ox-LDL水平明显下降,颈动脉IMT、RI明显变小,高密度脂蛋白胆固醇、NO水平明显升高,差异有统计学意义(P<0.05),对照组治疗前、后各指标无明显变化。结论:调脂治疗对ICVD患者具有保护血管内皮及稳定动脉粥样硬化斑块的作用。
Objective: To investigate the effect of lipid-lowering therapy on carotid plaque in patients with ischemic cerebrovascular disease (ICVD). Methods: Seventy-eight ICVD patients with carotid atherosclerosis were randomly divided into Xuezhikang group and control group. Xuezhikang group was treated with Xuezhikang and aspirin for 6 months. The control group received aspirin only. The levels of carotid intima-media thickness (IMT), blood flow resistance index (RI) and blood lipid, serum nitric oxide (NO) and ox-LDL Variety. Results: The levels of TC, TG, LDL-C and ox-LDL in Xuezhikang group were significantly lower than those before treatment, and the IMT and RI of carotid artery were obviously changed Small, high density lipoprotein cholesterol, NO levels were significantly increased, the difference was statistically significant (P <0.05), the control group before and after treatment, no significant change in each indicator. Conclusion: Lipid-lowering therapy can protect vascular endothelial and stabilize atherosclerotic plaque in ICVD patients.