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目的分析妊娠中期产前诊断的高危孕妇羊水细胞染色体核型,了解异常核型出现的频率、类型及与各种产前诊断指征的关系。方法 1446例有产前诊断指征的孕妇,妊娠16W-28W,抽取羊水细胞进行培养及染色体核型分析。结果在1446例羊水染色体核型分析中,发现异常核型47例,占3.25%。结论对有指征的孕妇行羊水染色体检查是必要的,对减少染色体异常胎儿出生有重要意义。
Objective To analyze the chromosomal karyotypes of amniotic fluid cells in prenatal diagnosis of prenatal pregnancy and to find out the frequency and types of abnormal karyotypes and the relationship with various prenatal diagnosis indications. Methods 1446 pregnant women with prenatal diagnosis indications, pregnancy 16W-28W, extracted amniotic fluid cells for culture and karyotype analysis. Results In 1446 cases of amniotic fluid karyotype analysis, abnormal karyotypes were found in 47 cases (3.25%). Conclusions Pregnant women with indications for amniotic fluid chromosome examination is necessary to reduce chromosomal abnormalities fetal birth is of great significance.