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目的：观察雷公藤制剂的副作用。方法：应用雷公藤制剂治疗类风湿关节炎（ＲＡ）患者２７１例，并观察其副作用发生情况。结果：雷公藤叶提取物雷诺酯片比雷公藤根提取物雷公藤片对生殖系统影响小。雷公藤根蕊提取物雷公藤多甙片在治疗ＲＡ中，每日６０ｍｇ大剂量比每日３０ｍｇ小剂量副作用发生率高（Ｐ＜００１）。＜５０岁女性患者主要副作用以月经失调为主；＞５０岁患者要注意对肾脏的影响。在长期应用中，雷公藤多甙片的副作用主要发生在前１０年。雷公藤多甙片应用在湿热瘀阻型ＲＡ比肝肾阴虚型ＲＡ副作用发生率低（Ｐ＜００５）。结论：雷诺酯片适用于青年女性患者。雷公藤多甙片小剂量适应维持治疗，而以治疗湿热瘀阻型患者为佳。
Objective: To observe the side effects of Tripterygium wilfordii preparation. Methods: 271 cases of rheumatoid arthritis (RA) were treated with Tripterygium wilfordii preparation and the side effects were observed. Results: Tripterygium wilfordii leaves renol ester tablets had less effect on reproductive system than Tripterygium wilfordii root extract Tripterygium wilfordii. Tripterygium wilfordii extract Tripterygium wilfordii has a higher incidence of high-dose 60 mg daily than low-dose 30 mg daily side effects in the treatment of RA (P < 0.01). <50-year-old female patients mainly suffer from menstrual disorders;> 50-year-old patients should pay attention to the impact of the kidney. In long-term applications, the side effects of Tripterygium wilfordii mainly occur in the first 10 years. Tripterygium wilfordii has a lower incidence of side-effects in damp-heat phlegm-reactive RA than liver-kidney yin-deficiency RA (P<005). Conclusion: Renault ester tablets are suitable for young female patients. Tripterygium glycosides are suitable for maintenance therapy in small doses, and it is preferable to treat patients with hot and humid phlegm.