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目的探讨急性肾小球肾炎（ＡＧＮ）并发严重循环充血状态时心肌酶学改变及其临床意义。方法对７２例无并发症的ＡＧＮ和２６例并发严重循环充血状态的ＡＧＮ患儿血中天冬氨酸转氨酶（ＡＳＴ）、肌酸激酶（ＣＫ）、肌酸激酶同功酶（ＣＫ－ＭＢ）、乳酸脱氢酶（ＬＤＨ）及ＬＤＨ－１的含量进行测定。结果无并发症的ＡＧＮ患儿ＡＳＴ、ＣＫ、ＣＫ－ＭＢ、ＬＤＨ及ＬＤＨ－１均在正常范围，与正常健康儿童对照均无显著性差异（Ｐ均＞００５），而并发严重循环充血状态的ＡＧＮ患儿ＡＳＴ、ＣＫ及ＬＤＨ均明显高于正常健康儿童，而ＣＫ－ＭＢ及ＬＤＨ－１仍在正常范围。结论测定血清心肌酶对判断ＡＧＮ是否并发严重循环充血有较大参考价值。
Objective To investigate the changes of myocardial enzymes in patients with acute glomerulonephritis (AGN) complicating severe circulatory congestion and their clinical significance. Methods Serum aspartate aminotransferase (AST), creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) were measured in 72 patients with AGN without complications and 26 with AGN in patients with severe circulatory congestion. , Lactate dehydrogenase (LDH) and LDH-1 content were measured. Results There was no significant difference in AST, CK, CK-MB, LDH and LDH-1 among AGN children without complication (P> 0.05), but severe circulatory congestion The levels of AST, CK and LDH in AGN children were significantly higher than those in healthy children, while CK-MB and LDH-1 were still in the normal range. Conclusion The determination of serum myocardial enzymes for judging AGN complicated by severe circulatory congestion have greater reference value.