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目的 探讨TNF -α、IL - 6在慢性乙肝不同阶段的作用及双利肝对于两种细胞因子的影响。方法 5 5例慢性乙肝患者在治疗前测定血清TNF -α、IL - 6水平及肝功能。在一般保肝治疗基础上口服双利肝 ,在治疗前后测定血清TNF -α、IL - 6水平及肝功能。结果 随着肝功能损害加重 ,TNF -α、IL - 6水平显著升高 (P <0 0 1,P <0 0 5 ) ,经过双利肝治疗 ,患者转氨酶、胆红素、TNF -α水平明显下降 (P <0 0 1) ,IL - 6水平略有上升但无显著性差异 (P >0 0 5 )。结论 慢性乙肝病程中 ,TNF -α与肝细胞坏死程度有关 ,可作为病情轻重的判别指示。IL - 6与肝脏损伤过程有关。双利肝可明显降低慢性乙肝患者TNF -α水平 ,有效地改善肝功能
Objective To investigate the effects of TNF-α and IL-6 in different phases of chronic hepatitis B and the effects of Shuangli Liver on the two cytokines. Methods Fifty five patients with chronic hepatitis B before treatment were measured serum TNF - α, IL - 6 levels and liver function. On the basis of general hepatoprotective therapy, Shuangli Liver was given orally, and serum TNF-α, IL-6 levels and liver function were measured before and after treatment. Results With the aggravation of liver function, the levels of TNF-α and IL-6 were significantly increased (P <0.01, P <0.05). After treatment with Shuangli Liver, the serum levels of aminotransferase, bilirubin and TNF- (P <0.01), IL - 6 level increased slightly but no significant difference (P> 0.05). Conclusions In the course of chronic hepatitis B, TNF-α is related to the degree of hepatocyte necrosis and can be used as a discriminant indicator of the severity of the disease. IL - 6 is related to liver damage process. Shuangli Liver can significantly reduce the level of TNF-α in patients with chronic hepatitis B, effectively improve liver function