使用４种α－干扰素的９８例病毒性肝炎病人，在治疗前、治疗期间及治疗后定期检测抗干扰素中和抗体，结果发现阳性率为３４．７％，该抗体的产生与病人的性别、年龄、治疗前ＡＬＴ水平、肝炎病毒感染类型、以及肝炎的临床类型均无显著相关；低剂量干扰素较易产生中和抗体；使用不同干扰素制剂产生中和抗体存在差异，其中以ｒＩＦＮα２ａ最高，ＩＦＮαＮ１最低；但中和抗体的出现对干扰素的抗病毒疗效影响不大，由于病例数较少，干扰素治疗期间出现的肝炎再活动现象与抗干扰素中和抗体产生的关系，未能下结论。 A total of 98 patients with viral hepatitis using 4 interferon-alpha were regularly tested for anti-interferon neutralization before, during, and after treatment and found to have a positive rate of 34.7% Gender, age, ALT level before treatment, type of hepatitis virus infection, and clinical type of hepatitis were not significantly correlated; low-dose interferon more likely to produce neutralizing antibodies; interferon formulations used to produce neutralizing antibodies there are differences, including rIFN  α2a highest IFN  N1 lowest; but the emergence of neutralizing antibodies on the antiviral effect of interferon has little effect, due to the small number of cases, interferon treatment of hepatitis reactivation and anti-interferon neutralization antibody production The relationship failed to reach a conclusion.