论文部分内容阅读
目的:观察山仙颗粒对肝癌气虚血瘀证模型动物侵袭转移相关因子(MVD、VEGF)表达的影响。方法:将60只雄性ICR小鼠随机分成4组:15只为空白对照组(A组),气虚血瘀造模,另45只为实验组,全部进行肿瘤造模及气虚血瘀造模,每组15只,分别为:肿瘤模型组(B组),山仙颗粒组(C组),羟基喜树碱组(D组)。观察山仙颗粒对各组小鼠VEGF、MVD表达的影响。结果:山仙颗粒组(C组)VEGF、MVD的表达显著低于肿瘤模型组(B组)及对照药物羟基喜树碱组(D组)。结论:山仙颗粒具有抗气虚血瘀证肝癌侵袭、转移的作用。
Objective: To observe the effect of Shanxian Granules on the expression of invasiveness-related factors (MVD, VEGF) in liver cancer patients with Qi deficiency and blood stasis syndrome. METHODS: Sixty male ICR mice were randomly divided into four groups: fifteen blank control groups (group A), qi-deficiency and blood-stasis models, and another 45 experimental groups. All tumor models and qi deficiency and blood stasis models were performed. There were 15 mice in each group: tumor model group (group B), Shanxian granule group (group C), and hydroxycamptothecin group (group D). Observe the effect of Shanxian Granules on the expression of VEGF and MVD in mice. Results: The expression of VEGF and MVD was significantly lower in Shanxian granule group (C group) than in tumor model group (B group) and control group hydroxycamptothecin (D group). Conclusion: Shanxian granules have the effect of resisting the invasion and metastasis of hepatocellular carcinoma in Qi Deficiency and Blood Stasis Syndrome.