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To obtain useful information for identifying inhibitors of urate transporter 1 (URAT1),three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis was conducted for a series of lesinurad analogs via Topomer comparative molecular field analysis (CoMFA).A 3D-QSAR model was established using a training set of 51 compounds and extally validated with a test set of 17 compounds.The Topomer CoMFA model obtained (q2 =0.976,r2=0.990) was robust and satisfactory.Subsequently,seven compounds with significant URAT1 inhibitory activity were designed according to the contour maps produced by the Topomer CoMFA model.