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[目的]探讨CEA、CYFRA21-1和NSE对肺癌化疗疗效的预测价值。[方法]采用电化学发光法测定140例肺癌(腺癌62例,鳞癌46例,小细胞癌32例)患者化疗前后血清CEA、CYFRA21-1、NSE的水平,并分析其表达水平与病理类型及疗效的关系。[结果]腺癌CEA水平高于鳞癌和小细胞癌(P<0.01),鳞癌CYFRA21-1水平高于腺癌和小细胞癌(P<0.01),小细胞肺癌NSE水平高于腺癌和鳞癌(P<0.01)。化疗有效(CR+PR)的患者中,腺癌CEA较化疗前明显下降(t=3.126,P<0.01),鳞癌CYFRA21-1较化疗前明显下降(t=2.905,P<0.01),小细胞肺癌NSE较化疗前明显下降(t=3.216,P<0.01)。[结论]CEA、CYFRA21-1和NSE分别在肺腺癌、鳞癌及小细胞肺癌中高表达。3种肿瘤标志物的测定有助于肺癌疗效判断和预后评估。
[Objective] To investigate the predictive value of CEA, CYFRA21-1 and NSE in the efficacy of chemotherapy for lung cancer. [Method] The levels of serum CEA, CYFRA21-1 and NSE in 140 cases of lung cancer (62 cases of adenocarcinoma, 46 cases of squamous cell carcinoma and 32 cases of small cell carcinoma) before and after chemotherapy were determined by the method of electrochemiluminescence. The expression level and pathology Type and efficacy of the relationship. [Results] The level of CEA in adenocarcinoma was higher than that in squamous cell carcinoma and small cell carcinoma (P <0.01). The level of CYFRA21-1 in squamous cell carcinoma was higher than that in adenocarcinoma and small cell carcinoma (P <0.01) And squamous cell carcinoma (P <0.01). CEA in adenocarcinoma was significantly lower than that before chemotherapy (t = 3.126, P <0.01), and the expression of CYFRA21-1 in squamous cell carcinoma was significantly lower than that before chemotherapy (t = 2.905, P <0.01) The NSE of lung cancer was significantly lower than that before chemotherapy (t = 3.216, P <0.01). [Conclusion] CEA, CYFRA21-1 and NSE are highly expressed in lung adenocarcinoma, squamous cell carcinoma and small cell lung cancer respectively. The determination of three kinds of tumor markers contribute to the judgment and prognosis of lung cancer.