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目的：观察庆大霉素与聚氰基丙烯酸正丁酯毫微球结合以后，其体内抗菌活性（特别是对细胞内感染）是否有所增加。方法：以鼠伤寒沙门杆菌感染的Ｃ５７ＢＬ／６ｊ小鼠为细胞内感染的动物模型，以小鼠存活率和器官组织中的活菌计数为指标，对庆大霉素聚氰基丙烯酸正丁酯毫微球的体内抗菌活性进行评价。结果：从存活率评价其治疗指数提高了１０倍。肝、脾、肾中活菌计数最低可降至庆大霉素溶液组的１／４２６，１／１４１和１／３０。结论：与庆大霉素溶液相比，庆大霉素毫微球明显提高了对伤寒沙门杆菌感染小鼠的治疗效果。
OBJECTIVE: To observe whether the antibacterial activity in vivo (especially for intracellular infection) increased after gentamicin was combined with n-butyl polybutylcyanoacrylate microspheres. Methods: C57BL / 6j mice infected with Salmonella typhimurium were used as an animal model of intracellular infection. The survival rate of mice and the count of viable cells in organs and tissues were used as indexes. Gentamicin polybutylcyanoacrylate In vivo antibacterial activity of the nanospheres was evaluated. Results: The therapeutic index increased 10-fold from the survival rate. The minimum viable count in liver, spleen and kidney could be reduced to 1 / 426,1 / 141 and 1/30 in the gentamicin solution group. Conclusion: Compared with gentamicin solution, gentamicin nanospheres significantly increased the therapeutic effect on Salmonella typhimurium infected mice.