心、肾损害都是常见的临床疾病,二者相互影响,即称为心肾综合征(cardio-renal syndrome,CRS)。Ⅰ型心肾综合征是CRS的一种常见的重要亚型,其发病率、病死率高,应重视其诊断和治疗。本文对Ⅰ型心肾综合征的定义、流行病学、病理生理学机制进行阐述,重点探讨其相关生物标志物的研究进展和对临床的意义。 Heart and kidney damage are common clinical diseases, the two affect each other, which is called cardio-renal syndrome (CRS). Type I cardiomyopathy is a common and important subtype of CRS. Its morbidity and mortality are high, and its diagnosis and treatment should be emphasized. This article describes the definition, epidemiology and pathophysiology of type I heart-kidney syndrome, and focuses on the research progress and clinical significance of its related biomarkers.