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给低碘Wistar大鼠皮肤涂抹含碘制剂4个月后处死，测甲状腺含碘量，血清T4、FT4，并进行体视学观察结果发现；涂含碘制剂组（EI）甲状腺重量减少、甲状腺含碘量、血清T4、FT4较低碘对照组（EIF、C）均明显升高，并接近正常对照组（N）；甲状腺体视学参数显示低碘导致的甲状腺滤泡上皮增生、滤泡腔变小、胶质减少，滤泡边缘不规则等改变，经补碘4个月后发生逆转，体视学参数均趋于正常。可见通过皮肤渗透作用仍可达到补碘的效果；图象分析技术的应用对甲状腺形态变化进行量化，为深入研究甲状腺疾病提供了科学的依据。
The low iodine Wistar rat’s skin was smeared with iodine for 4 months and then sacrificed. The thyroid iodine, serum T4 and FT4 were measured and the results of stereological observation were observed. The iodine-containing preparation (EI) reduced thyroid weight, thyroid Iodine content, serum T4, FT4 lower iodine control group (EIF, C) were significantly elevated, and close to the normal control group (N); thyroid gland visual parameters showed thyroid follicular hyperplasia caused by low iodine, follicles Cavity smaller, glial decreased, irregular follicular edge changes, after 4 months of iodine reversed, stereological parameters tend to be normal. Visible through the skin infiltration can still achieve the effect of iodine supplements; image analysis technology to quantify changes in thyroid morphology, thyroid disease for further study provides a scientific basis.