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为了评价免疫血清球蛋白(ISG)预防非甲非乙型肝炎的效果,作者将291例输血的心外科手术病人随机分为两组,1组143例在输血前24小时及输血后1周,肌肉注射16%ISG10ml。另1组148例不施加任何保护措施。至调查结束时,除死亡和失访者外,对照组还有98例(62.2%),ISG组有100例(69.9%)。结果输血后非甲非乙型肝炎的发病情况为:对照组11例,占11.2%,ISG组仅3例,占3.0%(P=0.0203)。对照组11例中8例(72.7%)有症状,5例(45.4%)转为慢性,而ISG组中3例感染者具有自限性,其中仅1例有症状。对照组病人的转氨酶均高于ISG组病人的数值。潜伏期长于8周的与疾病转为慢性有关,ISG组病人的潜伏期均较短。发生
To evaluate the efficacy of immunoglobulin (ISG) in the prevention of non-A, non-B hepatitis, 291 patients undergoing transfusional cardiac surgery were randomly assigned to two groups. One group of 143 patients received 24 h before transfusion and one week after transfusion, Intramuscular injection of 16% ISG 10ml. Another group of 148 patients did not impose any protective measures. At the end of the survey, 98 (62.2%) of the control group and 100 (69.9%) of the ISG group, except for those who died and were lost. Results The incidence of non-A, non-B hepatitis after transfusion was 11 cases in the control group (11.2%) and only 3 cases in the ISG group (3.0%, P = 0.0203). Eighty patients (72.7%) in the control group had symptoms, and five (45.4%) became chronic, while three patients in the ISG group were self-limiting and only one had symptoms. The patients in the control group had higher transaminases than the patients in the ISG group. Latencies longer than 8 weeks are associated with chronic conditions, and patients with ISG have a shorter incubation period. occur