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反复低剂量的抗原刺激可引起哮喘患者气道反应性增高。作者采用对照、交叉实验方法观察反复低剂量抗原刺激对轻度过敏性哮喘患者气道炎症、气道反应性和症状的影响。 选择8例(男7例,女1例,年龄19～45岁)不吸烟、病史超过一年的轻度过敏性哮喘患者参加此项研究。受试者在进入研究前至少4周内无哮喘加重和呼吸道感染,7～8小时内未使用β_2受体激动剂和含咖啡的饮料,且过敏原筛选激发试验显示气道具有速发和迟发双重反应性。首先用稀释的抗原(比筛选激发试验所用抗原浓度低2～16倍)在上午8～10点对受试者进行连续5天的激发,在激发前和激发后30分钟
Repeated low-dose antigen stimulation can cause asthmatic patients with increased airway responsiveness. The authors used a controlled, crossover experiment to observe the effects of repeated low-dose antigen stimulation on airway inflammation, airway responsiveness and symptoms in patients with mild-to-severe asthma. Eight patients (7 males, 1 females, aged 19-45 years) who did not smoke and had mild allergic asthma who had a history of more than one year were included in the study. Subjects did not have asthma exacerbations and respiratory infections for at least 4 weeks prior to entering the study, did not use β 2 receptor agonists and coffee-containing drinks within 7-8 hours, and allergen screening challenge tests showed rapid and late onset of airway inflammation Dual reactive. Subjects were first challenged with diluted antigen (2 to 16 times lower than the concentration of antigen used in the screening challenge) at 8-10 am for 5 consecutive days prior to and 30 minutes after challenge