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目的:研究救必应酸在大鼠体内药动学和口服生物利用度。方法:建立测定大鼠血浆中救必应酸浓度的RP-HPLC法。考察大鼠经灌胃和尾静脉给予40 mg·kg~(-1)的救必应酸后血药浓度变化。采用3p97软件计算分析药动学参数和口服生物利用度。结果:灌胃组大鼠的Cmax为(0.81±0.22)μg·ml~(-1),Tmax为(45.24±5.13)min,T1/2为(101.47±8.25)min,AUC为(76.3±13.68)μg·min-1·ml~(-1);静脉注射组的T1/2为(73.68±11.02)min,AUC为(1 687.4±29.54)μg·min~(-1)·ml~(-1)。救必应酸口服利用度为4.52%。结论:救必应酸的口服生物利用度较差。
Objective: To study the pharmacokinetics and oral bioavailability of salidroside in rats. Methods: To establish a RP-HPLC method for the determination of salvate acid concentration in rat plasma. The change of plasma concentration of salvia miltiorrhiza bunge in rats fed with 40 mg · kg ~ (-1) gavage and tail vein was investigated. The pharmacokinetic parameters and oral bioavailability were calculated by 3p97 software. Results: The Cmax of the gavage group was (0.81 ± 0.22) μg · ml -1, the Tmax was (45.24 ± 5.13) min, the T1 / 2 was (101.47 ± 8.25) min and the AUC was (76.3 ± 13.68) The mean AUC was (1 687.4 ± 29.54) μg · min ~ (-1) · ml ~ (-1) · mL -1 in the intravenous injection group 1). Rescue should be acid oral utilization of 4.52%. Conclusions: The oral bioavailability of vasopressin is poor.