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目的研究瘦人非酒精性脂肪性肝病(NAFLD)的临床特征。方法从参加常规体检的1196例成人中,纳入219例诊断为NAFLD的患者,对瘦人[体质指数(BMI)<24 kg/m~2]与超重或肥胖(BMI≥24 kg/m~2)NAFLD患者的人口统计学、人体测量学、实验室检测指标和代谢并发症等特征进行比较。结果 219例NAFLD患者中,38例(17.4%)瘦人与181例(82.6%)超重或肥胖患者相比,男性比例更高(76.3%vs.58.6%,P=0.037),年龄较轻[(36.8±11.3)岁vs.(43.4±13.6)岁,P=0.006],舒张压[(83.7±7.5)mmHg vs.(83.1±8.2)mmHg]、收缩压[(129.6±7.8)mmHg vs.(131.4±9.3)mmHg]、空腹血糖[(5.46±0.83)μmol/L vs.(5.39±0.79)μ.mol/L]、总胆固醇[(6.48±1.37)mmol/L vs.(6.17±1.56)mmo/L、甘油三酯[(3.24±1.09)mmol/L vs.(3.32±0.94)mmol/L]、尿酸[(392.8±61.7)μmol/L vs.(388.5±59.6)μmol/L]和丙氨酸氨基转移酶[(32.6±8.9)IU/L vs.(31.3±9.6)IU/L]水平差异均无显著统计学意义(P值分别为0.906、0.395、0.725、0.326、0.837、0.864、0.416),高血压(28.9%vs.32.0%)、高血糖(26.3%vs.25.4%)、血脂异常(78.9%vs.76.2%)和高尿酸血症(34.2%vs.35.4%)患病率差异无统计学意义(P值分别为0.764、0.526、0.872、0.231)。结论与超重或肥胖患者相比,瘦人NAFLD患者的男性比例更高,年龄较轻,高血压、高血糖、血脂异常和高尿酸血症等代谢并发症的患病率无统计学差异。
Objective To study the clinical features of lean nonalcoholic fatty liver disease (NAFLD). Methods A total of 219 patients diagnosed with NAFLD were enrolled from 1196 adults who were enrolled in routine physical examinations. The patients with lean body mass index (BMI) <24 kg / m 2 and overweight or obesity (BMI ≥ 24 kg / m 2 ) Demographics, anthropometry, laboratory tests, and metabolic complications in NAFLD patients. Results Among 219 patients with NAFLD, 38 (17.4%) lean patients had a higher proportion of males than 76 patients (82.6%) overweight or obese (76.3% vs.58.6%, P = 0.037) (36.8 ± 11.3) years vs. (43.4 ± 13.6 years), P = 0.006], diastolic blood pressure (83.7 ± 7.5 mmHg vs. 83.1 ± 8.2 mmHg), systolic blood pressure (129.6 ± 7.8 mmHg vs. (131.4 ± 9.3) mmHg], fasting blood glucose [(5.46 ± 0.83) μmol / L vs. (5.39 ± 0.79) μ.mol / L], total cholesterol [(6.48 ± 1.37) mmol / L vs. (6.17 ± 1.56 (392.8 ± 61.7) μmol / L vs. (388.5 ± 59.6) μmol / L) and triglyceride (3.24 ± 1.09 mmol / L vs. 3.32 ± 0.94 mmol / L, And (32.6 ± 8.9) IU / L vs. (31.3 ± 9.6) IU / L] were not significantly different (P = 0.906,0.395,0.725,0.326,0.837, (28.9% vs.32.0%), hyperglycemia (26.3% vs.25.4%), dyslipidemia (78.9% vs.76.2%) and hyperuricemia (34.2% vs.35.4% No significant difference in prevalence (P values were 0.764,0.526,0.872,0.231). Conclusion Compared with overweight or obese patients, there is a higher proportion of male patients with lean NAFLD. The prevalence of metabolic complications such as younger age, hypertension, hyperglycemia, dyslipidemia and hyperuricemia are not statistically different.