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报告1例SLE患者伴有严重的难治性血小板减少,在其它治疗失败后以小剂量环磷酰胺(CTX)静脉注射治疗成功。患者女性,38岁,因乏力、易青肿和鼻衄一周而入院。患者7年前曾因严重血小板减少、抗核抗体(ANA)1:320及抗DNA抗体滴度升高诊断为SLE,以强的松60mg/d及脾切除治疗后,血小板计数恢复正常而出院,随后一直失访。本次入院时患者血小板9000/mm~3,ANA滴度1:2560,抗DNA水平1.6μ/ml(正常0～1),血沉70mm/hr,C_350mg％(0.5
One patient with SLE was reported to have severe refractory thrombocytopenia who was successfully treated with a low dose of cyclophosphamide (CTX) intravenously after other treatments failed. Female, 38 years old, admitted to hospital for one week because of weakness, bruising, and epistaxis. The patient was diagnosed with SLE 7 years after severe thrombocytopenia, antinuclear antibody (ANA) 1: 320 and anti-DNA antibody titer, and was released after prednisone 60 mg / d and splenectomy , Then has been lost. The admission of patients with platelets 9000 / mm ~ 3, ANA titer of 1: 2560, anti-DNA level of 1.6μ / ml (normal 0 to 1), erythrocyte sedimentation rate 70mm / hr, C_350mg%