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用大鼠和离体兔肺动脉环实验模型观察钙（Ca(2＋)）、钾（K＋）、钠（Na＋）对缺氧性肺血管收缩（HPV）的影响。整体实验发现:随血Ca(2+)、Na+浓度增高，HPV显著增强。血K+浓度升高0.36mmol／L，HPV明显减弱;血K+浓度继续升高，HPV又明显增强。离体实验发现:营养液中Ca(2+)浓度由0mmol／L逐步升高至10.0mmol／L的过程中，HPV明显增强。Na+浓度由35mmol／L升至220mmol／L过程中，HPV明显减弱。K+浓度由0mmol／L升高至6mmol／L，HPV明显减弱;继续升高至20mmol／L，HPV又明显增强。机理可能为细胞外钙浓度升高，缺氧时进入细胞内Ca(2+)增多，使HPV增强;K+、Na+主要通过影响细胞膜电位和离子交换起作用。
The effects of calcium (Ca2 +), potassium (K +) and sodium (Na +) on hypoxic pulmonary vasoconstriction (HPV) were observed using rat pulmonary artery rings. The overall experiment found: with the blood Ca (2 +), Na + concentration increased, HPV was significantly enhanced. Blood K + concentration increased 0.36mmol / L, HPV was significantly weakened; blood K + concentration continued to rise, HPV was significantly enhanced. In vitro experiments showed that: during the process of Ca (2+) concentration in nutrient solution gradually increased from 0 mmol / L to 10.0 mmol / L, HPV was significantly enhanced. During the process of increasing Na + concentration from 35mmol / L to 220mmol / L, HPV was significantly weakened. K + concentration increased from 0mmol / L to 6mmol / L, HPV was significantly weakened; continue to rise to 20mmol / L, HPV was significantly enhanced. Mechanism may be increased extracellular calcium concentration, hypoxia into the cell increased intracellular Ca2 +, HPV increased; K +, Na + mainly by affecting the membrane potential and ion exchange role.