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三叉神经脊束核尾侧亚核（Vc）和脊髓后角浅层（Ⅰ层和Ⅱ层）主要接受无髓和薄髓初级传入纤维，是伤害性刺激信息向中枢传递的初级门户，再经其内的伤害性感受神经元将伤害性刺激信息向丘脑传递。丘脑内接受伤害性刺激的特异性核团主要是腹后内侧核（VPM）和腹后外侧核（VPL）
The caudal subnucleus (Vc) of the trigeminal nucleus and the superficial layers of the posterior horn of the spinal cord (primary and secondary laminae) mainly accept the primary afferent fibers of the unmyelinated and medullary pulp and are the primary portals of transmission of nociceptive stimuli to the central nervous system The nociceptive neurons transmit the nociceptive information to the thalamus. The specific nuclei that receive nociceptive stimuli in the thalamus are mainly the ventral medial retrorse velamen (VPM) and the lateral ventral retrograde nucleus (VPL)