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目的：检测胃粘膜细胞表面是否存在与幽门螺杆菌（HelicobactorPylori，HP）特异性相结合的受体物质。方法：采用酶免疫亲和法检测胃、肝、肠组织细胞上的HP受体祥物质（HPReceptor－LikeSubstance，HPRLS），用大肠杆菌、空肠弯曲菌作受体的特异性试验以确定其特异性。结果：HPRLS仅在胃粘膜有较高的表达。与肝细胞、肠粘膜细胞相比差异具有显著性（P＜0.01）。特异性试验表明HPRLS仅能与HP结合，与大肠杆菌及空肠弯曲菌不能结合。结论：胃粘膜上皮细胞存在HP受体，肝细胞及肠粘膜细胞无此物质的表达。HPRLS只能与HP结合而不能与大肠杆菌、空肠弯曲菌结合，HP可能通过其表面的粘多糖与HPRLS相结合。
OBJECTIVE: To detect the presence or absence of receptors on the surface of gastric mucosal cells that bind to Helicobacter pylori (HP). Methods: HPReceptor-Like Substances (HPRLS) were detected by enzyme-immunoaffinity method in the stomach, liver and intestine. The specificity of Escherichia coli and Campylobacter jejuni as recipients was tested to determine their specificity . Results: HPRLS was only expressed in gastric mucosa. Compared with hepatocytes and intestinal mucosal cells, the difference was significant (P <0.01). Specificity tests showed that HPRLS only binds to HP and can not bind to Escherichia coli and Campylobacter jejuni. Conclusion: There is no HP receptor in gastric mucosal epithelial cells, hepatocytes and intestinal mucosa cells without the expression of this substance. HPRLS can only bind to HP but not to E. coli, Campylobacter jejuni, and HP may bind to HPRLS through its surface mucopolysaccharide.