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目的研究不同钙摄入量对于青春前期女童骨量增长的影响,为该人群钙适宜摄入量的修订提供科学依据。方法以年龄10.0±0.7岁的241名青春前期健康女童为对象,设计普通膳食组、牛奶补充组和钙剂补充组三组,总钙摄入量分别为600、900和1200mg/d,进行2年干预,采用多次称量及3d膳食询问法获得2年间日均膳食钙摄入量,使用双能X线骨密度仪测量干预前后全身、腰椎及近端股骨骨矿物密度和骨矿物含量。结果2年间三组的平均钙摄入量分别为552±61、864±139和1166±207mg/d;日均钙摄入量与全身、多位点骨矿物含量和骨矿物密度显著正相关;当日均钙摄入量达到864mg/d时,全身骨矿物含量增加值显著高于钙摄入量为552mg/d膳食组;当日均钙摄入量达到1166mg/d时,股骨颈骨矿物含量及骨矿物密度和腰椎骨矿物密度的增加值显著高于未达到1166mg/d的干预组。结论9～11.5岁的青春前期女童钙摄入量达到1166mg/d,全身特别是负重部位能获得较高骨矿物含量和骨矿物密度增长,提示青春前期钙适宜摄入量可能为1200mg/d。
Objective To study the effect of different calcium intake on bone mass gain in early adolescent girls and to provide a scientific basis for the revision of calcium intake in this population. Methods 241 healthy adolescent girls aged 10.0 ± 0.7 years old were enrolled in this study. The normal diet group, the milk supplementation group and the calcium supplementation group were designed. The total calcium intake was 600, 900 and 1200 mg / Year intervention, the average daily dietary calcium intake was obtained by weighing and 3-D dietary interrogation for two years. The mineral density and bone mineral content of the whole body, lumbar spine and proximal femur were measured before and after intervention by dual-energy X-ray absorptiometry. Results The mean calcium intake of the three groups was 552 ± 61,864 ± 139 and 1166 ± 207 mg / d respectively in two years. The daily average calcium intake was significantly and positively related to the total body, multi-site bone mineral content and bone mineral density. When the average daily calcium intake reached 864mg / d, the added value of total body bone mineral content was significantly higher than that of the 552mg / d dietary group. When the average daily calcium intake reached 1166mg / d, the femoral neck bone mineral content and Bone mineral density and lumbar bone mineral density increased significantly higher than did not reach 1166mg / d intervention group. Conclusion Calcium intake of 11 ~ 15 mg of adolescent girls aged 9 ~ 11.5 years reaches 1166mg / d, and the increase of bone mineral density and bone mineral density can be obtained in the whole body, especially in the area of weight bearing, which suggests that the intake of calcium in early adolescence may be 1200mg / d.