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目的:观察抗抑郁药路优泰(圣.约翰草提取物)对冠心病-不稳定型心绞痛(UA)合并抑郁症状患者治疗的疗效。方法:将62例不稳定型心绞痛合并抑郁症状的患者随机分为观察组和对照组。观察组在常规药物治疗基础上给予路优泰300mg,日3次口服;对照组给予单纯常规药物治疗。于治疗后4周观察两组间心前区疼痛和心电图的变化情况,并采用SDS、HAMD抑郁量表进行动态评估。结果:观察组4周内抑郁情绪及心前区疼痛症状明显改善,与对照组比较有显著性差异(P<0.05)。结论:路优泰能有效的减轻冠心病患者的抑郁情绪,改善不稳定型心绞痛患者心前区疼痛症状,这种治疗更有利于冠心病的控制。
Objective: To observe the curative effect of antidepressant Luyutai (St. John’s wort extract) on the treatment of coronary heart disease-unstable angina pectoris (UA) with depressive symptoms. Methods: 62 patients with unstable angina pectoris and depression were randomly divided into observation group and control group. The observation group was treated with Luyutai 300mg on the basis of conventional drug treatment, 3 times daily orally; the control group was given simple routine drug treatment. Four weeks after the treatment, changes in the anterior paresis pain and electrocardiogram (ECG) between the two groups were observed and evaluated by SDS and HAMD Depression Rating Scale. Results: The symptoms of depression and precordial pain in observation group were significantly improved within 4 weeks, which were significantly different from those in control group (P <0.05). Conclusion: Lu You Tai can effectively alleviate the depression in patients with coronary heart disease and improve the precordial pain in patients with unstable angina. This treatment is more conducive to the control of coronary heart disease.