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药物制剂在胃肠道停留的时间,可直接影响某些药物的生物利用度。如有些药物在口服的同时进食或同服普鲁本辛,可延长在胃肠道停留的时间,而增加其生物利用度。本文利用生物聚合物与生物膜表面互相粘附而发生作用的原理,把双氢氯噻嗪(HCT)制成两种制剂,一种是用聚丙烯酸制成HCT 生物粘附剂,它能减缓口-盲肠的转运速度;另一种是用1.5%羟乙基纤维素(HEC)制成非粘附性制剂,分别研究它们的流变学特性和生物利用度。
The time it takes for a drug formulation to stay in the gastrointestinal tract can directly affect the bioavailability of some drugs. If some of these drugs are orally administered at the same time or with clothespulpirin, can prolong the stay in the gastrointestinal tract, while increasing its bioavailability. In this paper, biopolymer and biofilm surface adhesion effect with each other principle, the hydrochlorothiazide (HCT) made of two preparations, one is made of polyacrylic acid HCT bioadhesive agent, it can slow down the mouth - cecum The other is to make non-adherent preparation with 1.5% hydroxyethylcellulose (HEC) and study their rheological properties and bioavailability separately.