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基膜(又称基底膜)属细胞外间质。基膜主要有两种,一种是分隔上皮与结缔组织的膜,称为上皮组织基膜;另一种分隔结缔组织与血管的膜,称为血管内皮基膜。抗IV型胶原和基膜粘连蛋白(lamimin)的多克隆抗体能识别这两种基膜。传统的PAS染色能显示这两种基膜。但也显示基膜外其他多糖类物质。作者在研制抗鼻咽癌单克隆抗体的同时获得一株杂交瘤细胞株,其分泌的抗体(命名为CAN181)
Basement membrane (also known as basement membrane) is an extracellular matrix. There are two kinds of basement membranes, one is the membrane that separates the epithelium and the connective tissue, which is called the epithelial tissue basement membrane; the other is the membrane that separates the connective tissue from the blood vessels and is called the vascular endothelium basement membrane. Polyclonal antibodies against type IV collagen and laminin recognize both basement membranes. Traditional PAS staining can show both base films. However, other polysaccharides outside the basement membrane are also shown. The authors obtained a hybridoma cell line at the same time as developing anti-nasopharyngeal cancer monoclonal antibody, and the secreted antibody (named CAN181)